Fri Apr 01 2022

35 articles - From Saturday Mar 26 2022 to Friday Apr 01 2022

parm_toc.knit

Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…

Rheumatology (Oxford)

British Society for Rheumatology guideline on management of paediatric, adolescent and adult patients with idiopathic inflammatory myopathy.

Pubmed   Journal   ReadQx 


Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Ann Rheum Dis

Anifrolumab efficacy and safety by type I interferon gene signature and clinical subgroups in patients with SLE: post hoc analysis of pooled data from two phase III trials.

Overall, this study supports the consistent efficacy and safety of anifrolumab across a range of patients with moderate-to-severe SLE. In a few subgroups, small sample sizes limited conclusions from being drawn regarding the treatment benefit with anifrolumab.

Pubmed   Journal   ReadQx 

Longitudinal analysis of ANA in the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort.

In recent-onset SLE, three ANA assays demonstrated commutability with a high proportion of positivity and titres or AU. However, over 5 years follow-up, there was modest variation in ANA assay performance. In clinical situations where the SLE diagnosis is being considered, a negative test by either the ELISA or HEp-2 IFA may require reflex testing.

Pubmed   Journal   ReadQx 

Outcomes of SARS-CoV-2 infection among children and young people with pre-existing rheumatic and musculoskeletal diseases.

This is the most significant investigation to date of COVID-19 in CYP with RMDs. It is important to note that the majority of CYP were not hospitalised, although those with severe systemic RMDs and obesity were more likely to be hospitalised.

Pubmed   Journal   ReadQx 

Arthritis Care Res (Hoboken)

Calcaneal bone marrow lesions and plantar fascia imaging biomarkers are associated with chronic plantar heel pain: a case-control study.

Calcaneal BMLs and plantar fascia imaging biomarkers are associated with CPHP. Further research is required to understand whether these different markers represent distinct phenotypes of heel pain, and if so, whether there are specific treatment implications.

Pubmed   Journal   ReadQx 

Loss of Productivity-Adjusted Life Years in Working-age Australians Due To Knee Osteoarthritis: A Life-table Modelling Approach.

Our modelling demonstrates a significant economic burden of KOA among the working Australian population, with marked productivity loss. This highlights the need for public health funding and scalable population-level strategies for effective KOA prevention and support to maintain productive working.

Pubmed   Journal   ReadQx 

Pain sensitization as a potential mediator of the relationship between sleep disturbance and subsequent pain in rheumatoid arthritis.

Pain sensitization may be one mechanism through which sleep disturbance contributes to pain. The small magnitude of association indicates that unmeasured pathways may contribute to this relationship. Intervention studies are needed to establish causality and determine whether improving sleep can improve pain in patients with RA.

Pubmed   Journal   ReadQx 

Arthritis Res Ther

Differences in topographical location of sacroiliac joint MRI lesions in patients with early axial spondyloarthritis and mechanical back pain.

AxSpA patients demonstrated a widespread distribution of both inflammatory and structural changes, including high BME occurrence in the ligamentous joint portions whereas patients with MBP had the highest occurrence of BME in the middle anterior sacrum. These findings may help differentiate axSpA patients from other back pain conditions in the early diagnostic phase.

Pubmed   Journal   ReadQx   PMC

Effect of resistance exercise on serum leptin levels in a prospective longitudinal study of women patients with rheumatoid arthritis.

In addition to muscle strength and exercise capacity, the 12 weeks of individualized resistance exercise reduced serum leptin levels in keeping with body fat mass or visceral fat area, suggesting that serum leptin levels might be a surrogate marker of exercise in RA.

Pubmed   Journal   ReadQx 

Observed efficacy and clinically important improvements in participants with osteoarthritis treated with subcutaneous tanezumab: results from a 56-week randomized NSAID-controlled study.

Tanezumab and NSAID both provided early and sustained (up to 56 weeks) efficacy relative to baseline. Improvements in pain and function were clinically meaningful in a substantial proportion of participants. Adverse events of abnormal peripheral sensation and joint safety events occurred more frequently with tanezumab than with NSAID.

Pubmed   Journal   ReadQx 

Urinary galectin-3 binding protein (G3BP) as a biomarker for disease activity and renal pathology characteristics in lupus nephritis.

uG3BP is a non-invasive biomarker for clinically and histologically reflecting disease activity. It is associated with active histological changes and can be used as a surrogate biomarker when the renal biopsy is impractical.

Pubmed   Journal   ReadQx 

Arthritis Rheumatol

Adipose-Derived Regenerative Cell Transplantation in Systemic Sclerosis: Scleroderma Treatment with Celution Processed Adipose Derived Regenerative Cells- a Randomized Clinical Trial.

While the primary end point of this trial was not achieved, efficacy trends were observed in subjects with dcSSc. Adipose harvest and ADRC injection were demonstrated to be feasible. Further clinical trial of this intervention in dcSSc is warranted.

Pubmed   Journal   ReadQx 

Identification of Novel Loci Shared by Juvenile Idiopathic Arthritis Subtypes through Integrative Genetic Analysis.

This study identified novel genetic loci shared by JIA subtypes and nominated candidate mechanisms underlying JIA subtypes and candidate targets with possible drug repositioning opportunities for JIA treatment.

Pubmed   Journal   ReadQx 

Small molecule inhibitors of nuclear export ameliorate lupus by modulating plasma cell generation and survival.

Our collective results support the therapeutic potential of SINE via targeting several molecular and cellular pathways critical in lupus pathogenesis, including autoantibody production by plasma cells.

Pubmed   Journal   ReadQx 

Rheumatology (Oxford)

Advanced neural networks for classification of MRI in psoriatic arthritis, seronegative, and seropositive rheumatoid arthritis.

Neural networks can be successfully trained to distinguish MRI inflammation related to seropositive RA, seronegative RA, and PsA.

Pubmed   Journal   ReadQx 

Clinical integration of patient-reported outcome measures to enhance the care of patients with SLE: a multi-center prospective cohort study.

The remote capture and integration of electronic PROMs into clinical care was feasible in a diverse cohort of SLE outpatients. PROMs were useful to patients and enhanced their clinical experience primarily by facilitating communication.

Pubmed   Journal   ReadQx 

Effectiveness of sequential biologic and targeted disease modifying anti-rheumatic drugs for rheumatoid arthritis.

Many patients will eventually benefit after repeated trials of b/tsDMARD. Further research to improve treatment selection are needed to prevent prolonged trial and error approaches in some patients.

Pubmed   Journal   ReadQx 

Humoral Response and Safety of BNT162b2 mRNA Vaccine in Children with Rheumatic Diseases under Immunomodulatory Treatment: A Preliminary Study.

PedRD patients receiving immunomodulatory treatments were able to mount an effective humoral response after two dose regimens of BNT162b2 mRNA vaccine safely without interrupting their current treatments.

Pubmed   Journal   ReadQx 

Muscle involvement in systemic lupus erythematosus: multimodal ultrasound assessment and relationship with physical performance.

US assessment of muscle echogenicity and stiffness is useful for the early detection of muscle involvement in SLE patients.

Pubmed   Journal   ReadQx 

Osteophytes' position in subjects with DISH and right-sided aorta: verification of the "aortic pulsation protective effect" theory.

The aortic pulsation plays an important role in inhibiting the development of the osteophytes and results in majority of contralateral osteophytes on both right-sided and left-sided aortas. However, since both ipsilateral and bilateral osteophytes were not at al rare in both groups, other, yet to be established, parameters probably contribute to osteophytes location.

Pubmed   Journal   ReadQx 

Phenotype of limited cutaneous systemic sclerosis patients with positive anti-topoisomerase I antibodies: data from EUSTAR cohort.

ATA-lcSSc patients have a high risk of ILD, albeit with a lower risk of progression compared with ATA-dcSSc, supporting a careful screening for ILD in this subgroup.

Pubmed   Journal   ReadQx 

Statin-associated immune-mediated necrotizing myositis in native americans.

IMNM may occur in Native Americans and is associated with diabetes mellitus, hyperlipidemia, statin use, and older ages, and characterized by marked CK elevation, necrotizing myopathy, and anti-HMGCoA antibodies with few cutaneous or vascular manifestations.

Pubmed   Journal   ReadQx 

The performance of different classification criteria for systemic lupus erythematosus in a real-world rheumatology department.

The sensitivity and specificity of each set of classification criteria vary slightly, with SLICC 2012 and SLERPI 2020 having the highest sensitivities and the ACR 1997 criteria having the highest specificity in our patient cohort. All classification criteria serve as good instructional aids for clinicians to understand SLE manifestations. For the Australian Lupus Registry and Biobank, we will continue to use the ACR 1997 and/or SLICC 2012 as entry to the observational cohort.

Pubmed   Journal   ReadQx 


Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Arthritis Rheumatol

Arthritis & Rheumatology: "Mid-Term" Report.

Pubmed   Journal   ReadQx 


Letters&Replies

Letters to the editors and authors’ replies

Arthritis Rheumatol

Increased Risk of Statin-Associated Autoimmune Myopathy Among American Indians.

Pubmed   Journal   ReadQx 

On the perils of peeking into the future: comment on the article by Rosenthal and colleagues.

Pubmed   Journal   ReadQx 

The effect of body mass index on hand pain was not mediated via leptin: the Chingford 1000 women study.

Pubmed   Journal   ReadQx 


Others

all remaining publications eg case reports, images of the month, etc…

Ann Rheum Dis

Pilot study of baricitinib for active Sjogren's syndrome.

Pubmed   Journal   ReadQx 

Arthritis Rheumatol

Spinal gout.

Pubmed   Journal   ReadQx 

Rheumatology (Oxford)

Comment on: risk of major adverse cardiovascular events in patients initiating biologics/apremilast for psoriatic arthritis: a nationwide cohort study: Reply.

Pubmed   Journal   ReadQx 

Comment on: Risk of major adverse cardiovascular events in patients initiating biologics/apremilast for psoriatic arthritis: a nationwide cohort study: Reply.

Pubmed   Journal   ReadQx 

Increased antibody response after SARS-CoV-2 mRNA-based vaccination in rituximab-treated patients with previous COVID-19 infection.

Pubmed   Journal   ReadQx 

Influence of paternal inflammatory arthritis on pregnancy outcomes: more than meets the eye?

Pubmed   Journal   ReadQx 

Therapeutic effectiveness of upadacitinib combined with glucocorticoid on remission induction and maintenance in giant cell arteritis.

Pubmed   Journal   ReadQx 

Tumefactive lesion revealing neuro-Behçet disease.

Pubmed   Journal   ReadQx