35 articles - From Saturday Mar 26 2022 to Friday Apr 01 2022
Guidelines, position statements, white papers, technical reviews, consensus statements, etc…
| Rheumatology (Oxford) |
meta-analyses and systematic reviews
RCT, clinical trials, retrospective studies, etc…
| Ann Rheum Dis |
Anifrolumab efficacy and safety by type I interferon gene signature and clinical subgroups in patients with SLE: post hoc analysis of pooled data from two phase III trials. Overall, this study supports the consistent efficacy and safety of anifrolumab across a range of patients with moderate-to-severe SLE. In a few subgroups, small sample sizes limited conclusions from being drawn regarding the treatment benefit with anifrolumab. |
Longitudinal analysis of ANA in the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort. In recent-onset SLE, three ANA assays demonstrated commutability with a high proportion of positivity and titres or AU. However, over 5 years follow-up, there was modest variation in ANA assay performance. In clinical situations where the SLE diagnosis is being considered, a negative test by either the ELISA or HEp-2 IFA may require reflex testing. |
Outcomes of SARS-CoV-2 infection among children and young people with pre-existing rheumatic and musculoskeletal diseases. This is the most significant investigation to date of COVID-19 in CYP with RMDs. It is important to note that the majority of CYP were not hospitalised, although those with severe systemic RMDs and obesity were more likely to be hospitalised. |
| Arthritis Care Res (Hoboken) |
Calcaneal bone marrow lesions and plantar fascia imaging biomarkers are associated with chronic plantar heel pain: a case-control study. Calcaneal BMLs and plantar fascia imaging biomarkers are associated with CPHP. Further research is required to understand whether these different markers represent distinct phenotypes of heel pain, and if so, whether there are specific treatment implications. |
Loss of Productivity-Adjusted Life Years in Working-age Australians Due To Knee Osteoarthritis: A Life-table Modelling Approach. Our modelling demonstrates a significant economic burden of KOA among the working Australian population, with marked productivity loss. This highlights the need for public health funding and scalable population-level strategies for effective KOA prevention and support to maintain productive working. |
Pain sensitization as a potential mediator of the relationship between sleep disturbance and subsequent pain in rheumatoid arthritis. Pain sensitization may be one mechanism through which sleep disturbance contributes to pain. The small magnitude of association indicates that unmeasured pathways may contribute to this relationship. Intervention studies are needed to establish causality and determine whether improving sleep can improve pain in patients with RA. |
| Arthritis Res Ther |
Differences in topographical location of sacroiliac joint MRI lesions in patients with early axial spondyloarthritis and mechanical back pain. AxSpA patients demonstrated a widespread distribution of both inflammatory and structural changes, including high BME occurrence in the ligamentous joint portions whereas patients with MBP had the highest occurrence of BME in the middle anterior sacrum. These findings may help differentiate axSpA patients from other back pain conditions in the early diagnostic phase. |
Effect of resistance exercise on serum leptin levels in a prospective longitudinal study of women patients with rheumatoid arthritis. In addition to muscle strength and exercise capacity, the 12 weeks of individualized resistance exercise reduced serum leptin levels in keeping with body fat mass or visceral fat area, suggesting that serum leptin levels might be a surrogate marker of exercise in RA. |
Observed efficacy and clinically important improvements in participants with osteoarthritis treated with subcutaneous tanezumab: results from a 56-week randomized NSAID-controlled study. Tanezumab and NSAID both provided early and sustained (up to 56 weeks) efficacy relative to baseline. Improvements in pain and function were clinically meaningful in a substantial proportion of participants. Adverse events of abnormal peripheral sensation and joint safety events occurred more frequently with tanezumab than with NSAID. |
Urinary galectin-3 binding protein (G3BP) as a biomarker for disease activity and renal pathology characteristics in lupus nephritis. uG3BP is a non-invasive biomarker for clinically and histologically reflecting disease activity. It is associated with active histological changes and can be used as a surrogate biomarker when the renal biopsy is impractical. |
| Arthritis Rheumatol |
Adipose-Derived Regenerative Cell Transplantation in Systemic Sclerosis: Scleroderma Treatment with Celution Processed Adipose Derived Regenerative Cells- a Randomized Clinical Trial. While the primary end point of this trial was not achieved, efficacy trends were observed in subjects with dcSSc. Adipose harvest and ADRC injection were demonstrated to be feasible. Further clinical trial of this intervention in dcSSc is warranted. |
Identification of Novel Loci Shared by Juvenile Idiopathic Arthritis Subtypes through Integrative Genetic Analysis. This study identified novel genetic loci shared by JIA subtypes and nominated candidate mechanisms underlying JIA subtypes and candidate targets with possible drug repositioning opportunities for JIA treatment. |
Small molecule inhibitors of nuclear export ameliorate lupus by modulating plasma cell generation and survival. Our collective results support the therapeutic potential of SINE via targeting several molecular and cellular pathways critical in lupus pathogenesis, including autoantibody production by plasma cells. |
| Rheumatology (Oxford) |
Clinical integration of patient-reported outcome measures to enhance the care of patients with SLE: a multi-center prospective cohort study. The remote capture and integration of electronic PROMs into clinical care was feasible in a diverse cohort of SLE outpatients. PROMs were useful to patients and enhanced their clinical experience primarily by facilitating communication. |
Effectiveness of sequential biologic and targeted disease modifying anti-rheumatic drugs for rheumatoid arthritis. Many patients will eventually benefit after repeated trials of b/tsDMARD. Further research to improve treatment selection are needed to prevent prolonged trial and error approaches in some patients. |
Humoral Response and Safety of BNT162b2 mRNA Vaccine in Children with Rheumatic Diseases under Immunomodulatory Treatment: A Preliminary Study. PedRD patients receiving immunomodulatory treatments were able to mount an effective humoral response after two dose regimens of BNT162b2 mRNA vaccine safely without interrupting their current treatments. |
Osteophytes' position in subjects with DISH and right-sided aorta: verification of the "aortic pulsation protective effect" theory. The aortic pulsation plays an important role in inhibiting the development of the osteophytes and results in majority of contralateral osteophytes on both right-sided and left-sided aortas. However, since both ipsilateral and bilateral osteophytes were not at al rare in both groups, other, yet to be established, parameters probably contribute to osteophytes location. |
Phenotype of limited cutaneous systemic sclerosis patients with positive anti-topoisomerase I antibodies: data from EUSTAR cohort. ATA-lcSSc patients have a high risk of ILD, albeit with a lower risk of progression compared with ATA-dcSSc, supporting a careful screening for ILD in this subgroup. |
Statin-associated immune-mediated necrotizing myositis in native americans. IMNM may occur in Native Americans and is associated with diabetes mellitus, hyperlipidemia, statin use, and older ages, and characterized by marked CK elevation, necrotizing myopathy, and anti-HMGCoA antibodies with few cutaneous or vascular manifestations. |
The performance of different classification criteria for systemic lupus erythematosus in a real-world rheumatology department. The sensitivity and specificity of each set of classification criteria vary slightly, with SLICC 2012 and SLERPI 2020 having the highest sensitivities and the ACR 1997 criteria having the highest specificity in our patient cohort. All classification criteria serve as good instructional aids for clinicians to understand SLE manifestations. For the Australian Lupus Registry and Biobank, we will continue to use the ACR 1997 and/or SLICC 2012 as entry to the observational cohort. |
Plenty of the editorials are available as full text through the publisher website using the provided link
Letters to the editors and authors’ replies
| Arthritis Rheumatol |
all remaining publications eg case reports, images of the month, etc…
| Ann Rheum Dis |
| Arthritis Rheumatol |
| Rheumatology (Oxford) |